尿路多环芳代谢物与睡眠障碍之间的关联:一个整合机器学习和网络毒理学的横截面研究
Yiren Bao1, Bo Liang2, Yankai Dong3
1Department of Massage, The Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, China.
The Journal of international medical research
|March 17, 2026
概括
对多环芳 (PAH) 的暴露与睡眠障碍有关. 这项研究确定了特定的PAH代谢物及其蛋白质标,为影响睡眠质量的机制提供了洞察力.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 睡眠科学 睡眠科学
背景情况:
- 人类面临着对多环芳 (PAHs) 的广泛暴露.
- 关于尿路PAH代谢物与睡眠障碍之间的联系的证据有限.
研究的目的:
- 研究尿路PAH代谢物对睡眠相关问题的影响.
- 通过网络毒理学识别PAH诱导的睡眠障碍中的关键蛋白质标.
主要方法:
- 从NHANES (2005-2012) 对3262名成年人的回顾性横截面研究.
- 利用11个机器学习算法来评估尿路PAH代谢物与睡眠障碍之间的关联.
- 网络毒理学和分子对接用于目标识别和验证.
主要成果:
- 随机森林和CatBoost算法确定了1-基二烯,2-基二烯,3-基二烯和3-基二烯作为关键污染物.
- 分子对接揭示了雄激素受体,B细胞淋巴瘤,NR3C1和TRPV1作为PAH对睡眠影响的关键标.
结论:
- 环境相关的PAH代谢物与睡眠障碍之间存在关联.
- 网络毒理学阐明了PAH引起的睡眠问题背后的潜在机制.
- 这些发现支持进一步的体内验证和针对性睡眠干预措施的开发.
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