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Updated: Mar 18, 2026

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含有瓦洛辛的蛋白质通过其ATPase活性在体外对抗FUS凝聚物的ATP驱动溶解

Hitomi Kimura1,2, Shin-Ichi Tate1,2,3,4,5, Kyota Yasuda1,2,3

  • 1Graduate School of Integrated Sciences for Life, Hiroshima University, Japan.

FEBS letters
|March 17, 2026
PubMed
概括

含有瓦洛辛蛋白 (VCP) 的ATPase活性防止高ATP下FUS凝结物的溶解,保持这些结构在神经退行性疾病中至关重要,如ALS. 这揭示了酶对相位分离的控制.

关键词:
腺三酸盐是什么?骨髓缩侧面硬化症 (ALS) 是一种在瘤中融化.液体液体相分离器 液体相分离器含有瓦洛的蛋白质.

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