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在各种器官的组织工程移植中促进血管生成的进展:综合性审查

Saeedeh Zare Jalise¹, Peiman Brouki Milan², Elham Kialashaki³

¹Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Qom University of Medical Sciences, Qom, Iran.

Macromolecular bioscience

|March 17, 2026

概括

本综述详细介绍了在组织工程中改善血管形成 (血管生成) 的策略. 生物材料,细胞疗法和3D生物打印等技术的进步是克服移植局限性的关键.

科学领域:

生物医学工程生物医学工程
再生医学是一种再生医学.
血管生物学血管生物学

背景情况:

血管化对于工程组织的生存和功能至关重要.
植入后缺血症限制了移植成功.
自然血管发育为工程解决方案提供了蓝图.

研究的目的:

审查最近在组织工程结构中促进血管生成的进展.
探索模仿自然血管发育的策略.
确定再生医学血管整合的挑战和未来方向.

主要方法:

控制的提供亲血管性生长因子 (VEGF,FGF,PDGF).
开发生物活性和机械调节的生物材料 (原,凝,氨酸,脱细胞化矩阵).
基于细胞的方法,使用干细胞和祖细胞 (ESC,iPSC,MSC).
新技术的应用,如3D生物打印和纳米制造.
探索非传统的诱导物,如寄生虫衍生的蛋白质.

主要成果:

多种策略显示出增强工程组织血管化的前景.
3D生物打印和细胞外囊泡可以改善对血管网络形成的控制.
对特定器官的应用表明了跨多种组织的翻译潜力.
非传统的血管性诱导剂提供了新的治疗途径.

结论:

实现稳定,长期的血管化仍然是一个重大挑战.
同步血管化与淋巴血管生成和免疫调节至关重要.
对于临床翻译,必须解决监管障碍.
跨学科的合作对于开发功能性组织替代物至关重要.

关键词:

血管新生的产生.生物材料是一种生物材料.增长因素增长因素增长因素器官器官器官再生医学是一种再生医学.

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