前十字带 (ACL) 重建中的骨科生物学:叙述性审查
Marko Ostojic1,2, Enrico Ragni3, Bruno Lovreković4,5
1Sports Traumatology Division, Traumatology Department "Draškovićeva", University Hospital "Sisters of Mercy", Zagreb, Croatia.
概括
像PRP和干细胞这样的骨髓生物学药物对前十字带重建 (ACLR) 有理论上的好处. 然而,目前的证据不一致,由于缺乏高质量的研究,因此尚未推常规使用.
科学领域:
- 整形外科 整形外科 整形外科
- 运动医学 运动医学
- 再生医学是一种再生医学.
背景情况:
- 前十字带 (ACL) 损伤在体育医学中很常见.
- 目前的ACL修复和重建 (ACLR) 方法面临着移植合并和临床结果的挑战.
- 脊椎生物学为增强ACLR中的生物过程提供了理论上的优势.
研究的目的:
- 在ACLR中审查有关骨科生物学的现有证据.
- 评估它们在移植体内,带化和临床结果中的有效性.
- 为了确定是否目前的常规使用是合理的.
主要方法:
- 一个叙事的文学评论从Embase,Cochrane和PubMed.
- 专注于研究在ACL修复和重建中研究脊椎生物学的研究.
- 强调移植的愈合和患者的结果.
主要成果:
- 整形生物学药物可以通过生长因子和再生细胞来增强本地生物过程.
- 一些研究表明积极的影响,但临床结果不一致.
- 缺乏关于制备和管理协议的共识.
结论:
- 在ACLR中支持骨科生物学的高质量证据有限.
- 不一致的结果和方法的异质性阻止了最终的结论.
- 目前不能推在ACLR中常规使用骨生物学药物;需要进一步的标准化研究.
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