下垂体功能的性差异化:明显的差异是青少年灵长类动物和动物
概括
在灵长类动物中,雌激素可以触发黄素化激素的激增,类似于月经周期. 这表明,早期的雄激素暴露不会阻止循环性淋巴激素控制系统的发展.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 神经内分泌学神经内分泌学
- 灵长类动物生理学
背景情况:
- 调节性腺激素分泌对于生殖功能至关重要.
- 动物模型表明,早期的雄激素暴露会永久影响生殖的神经内分泌控制.
- 早期的雄激素暴露对灵长类动物周期性性腺激素分泌的影响仍然不太清楚.
研究的目的:
- 调查灵长类动物早期的雄激素暴露是否会阻止循环性淋巴激素分泌的神经内分泌控制系统的发展.
- 为了确定雌激素是否可以诱导黄素化激素 (LH) 在成年 rhesus 子中激增.
主要方法:
- 使用了成年雄性和雌性 rhesus 子,经过淋巴切除以去除内源性类固醇.
- 在循环雌激素度的急性升高被管理.
- 化激素 (LH) 分泌模式受到监测.
主要成果:
- 在雄性和雌性 rhesus 子中,急性雌激素的使用成功诱导了 LH 激增.
- 这些诱导的激增模仿了在自然月经周期中观察到的自发LH激增的模式.
- 这些发现是在动物身上观察到的,这些动物在胎儿和产后发育过程中被证明暴露于雄激素.
结论:
- 在灵长类动物中,控制循环性淋巴激素分泌的神经内分泌控制系统,尽管早期暴露于雄激素,但仍有区别.
- 雌激素,而不是雄激素,似乎是成年灵长类动物中LH激增的主要触发因素.
- 这些发现与动物的观察结果形成鲜明对比,并突出了生殖神经内分泌编程中的特定物种差异.
相关概念视频
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