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3-乙二:与胚胎中的原性活性相关的体外效应

A I Caplan, E Zwilling, N O Kaplan

    Science (New York, N.Y.)
    |May 31, 1968
    PubMed
    概括

    在胚胎中,3-乙二氨酸会导致骨肌肉低成形,但尼古丁胺完全逆转这种效应. 这表明尼古丁胺胺依赖反应对于正常的肌肉和软骨细胞分化至关重要.

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    The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...