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结晶沉积物作为纤维素原替代物的可靠来源

P M Ness, H A Perkins

|April 20, 1979

概括

商用纤维素素是不可用的,这使得冷沉积物成为纤维素和第八因子替代物的可靠来源. 每个袋子至少含有250毫克的纤维素原,对于临床需求至关重要.

科学领域:

输血医学输血医学
血液学血液学血液学

背景情况:

由于纤维激素在商业上不可用,因此需要替代来源.
冰沉积物是已知的,但经常被忽视的纤维素和XIII因子的来源.

研究的目的:

量化来自多个血液银行的冷沉积物中的纤维素素水平.
重新强调冷沉积物的临床实用性,以替代纤维素原.

主要方法:

在88袋冷沉积物中测量纤维素素含量.
来自加利福尼亚州和俄勒冈州的五个不同的血液银行.

主要成果:

平均而言,冷沉积物袋至少含有250毫克的纤维素原.
纤维素含量因所处理的血体积而异.
结晶沉积物显示出II,V,IX,X,XI和XII因素的低水平.

结论:

低温沉积物是纤维素和第八因子替代疗法的可靠来源.
临床医生应考虑到商业纤维素素缺乏,将冷沉积物视为可行的替代品.

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