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在龙神经肌肉连接处的过氧化酶吸收的刺激依赖性改变

E Holtzman, A R Freeman, L A Kashner

Science (New York, N.Y.)

|August 20, 1971

概括

电刺激增强了的过氧化酶吸收到龙肌肉中的神经末端囊泡中,特别是在定期的刺激暂停时. 这表明间歇性神经元信号传递期间内细胞酶活性增加.

科学领域:

神经科学是一个神经科学.
细胞生物学细胞生物学
肌肉生理学肌肉生理学

背景情况:

龙伸展肌肉中的神经末端表现出囊泡运输.
马过氧化酶被用作细胞吸收的标记物.
电刺激可以影响神经递质释放和神经元活动.

研究的目的:

为了研究电刺激对的过氧化酶吸收到神经末端囊泡的影响.
为了确定定期中断刺激是否会影响这种吸收过程.

主要方法:

使用蜂过氧化酶的细胞化学演示.
将电刺激应用于龙伸展肌肉神经.
观察吸收到神经末内的小囊泡中.

主要成果:

电刺激增强了的过氧化酶吸收到神经末端囊泡中.
定期中断刺激特别增加了这种吸收.
这些发现表明间歇性发射器释放和内细胞分裂之间存在联系.

结论:

间歇性电刺激促进了神经终端中增强的内细胞分裂.
这种机制在高神经元活动期间维持突触囊泡池可能至关重要.

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