相关实验视频
Updated: Aug 8, 2026
07:42
Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
概括
哈姆斯特和老鼠的纤维肉瘤显示出非随机的染色体变化. 病毒或化学致癌物引起的瘤具有不同的型,尽管其组织结构相似.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 致癌的发生是致癌的产生.
背景情况:
- 纤维沙瘤是源于连接组织的恶性瘤.
- 致癌症可以由病毒剂或化学变异原体诱导.
- 染色体异常在癌症发育中很常见.
研究的目的:
- 为了研究由Rous瘤病毒和7,12-dimethylbenz(a) 炭素诱导的纤维瘤的染色体变异,在中国汉姆斯特和老鼠.
- 为了比较同一个宿主物种内的病毒诱导与化学诱导纤维沙瘤的型模式.
主要方法:
- 在中国仓鼠和老鼠中诱导纤维瘤,使用Rous瘤病毒和7,12-dimethylbenz (a) 炭烯.
- 瘤样本的组织学检查.
- 瘤细胞的型分析以确定染色体变异.
主要成果:
- 通过这两种方法诱导的纤维肉瘤表现出非随机的染色体变异.
- 在老鼠和中国仓鼠中由Rous瘤病毒诱导的瘤显示出明显的型模式.
- 在老鼠和中国仓鼠中,由7,12-二甲基引发的瘤也表现出独特的型特征.
- 尽管有组织学上的相似之处,但每个物种内的病毒诱导和化学诱导瘤具有完全不同的型模式.
结论:
- 病因因子 (病毒或化学物质) 显著影响诱导纤维沙瘤的染色体异常.
- 型模式可以区分病毒诱导和化学诱导的纤维沙瘤,即使在组织学上相似.
- 非随机染色体变异是纤维素瘤发展的标志,无论诱导剂如何.
相关概念视频
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Such genes that act...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:12Loss of Tumor Suppressor Gene Functions
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
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