大脑皮层中catecholamine的吸收:通过战斗诱导的适应性变化
Science (New York, N.Y.)
|June 8, 1973
概括
与压力作斗争改变了大脑对北上腺素 (NE) 的吸收. 慢性攻击降低了NE亲和力并增加了吸收点,而急性战斗也降低了NE亲和力和d-安非他胺敏感性.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 神经药理学神经药理学
背景情况:
- 大脑中catecholamine吸收过程对于神经递质调节至关重要.
- 压力,特别是像打架这样的社会压力,可以显著影响神经化学过程.
研究的目的:
- 为了研究战斗诱导的压力对大脑中catecholamine吸收的动力学的影响.
- 确定慢性和急性战斗如何影响北上腺素 (NE) 吸收和其通过d-安非他胺抑制.
主要方法:
- 评估不同战斗范式的小鼠大脑皮层同质体中诺亚上的动力学.
- 测量NE吸收的明显迈克利斯常数 (Km) 和最大速度 (Vmax).
- 确定d-安非他胺抑制NE吸收的抑制常数 (Ki).
主要成果:
- 长期受到攻击的小组子小鼠显示NE吸收的Km增加和d-安非他胺抑制的Ki增加,表明亲和力降低.
- 经过急性激烈的战斗后,雄性小鼠对NE吸收的Km和Vmax增加,这表明亲和力减少,吸收地点更多.
- 在战斗后18-20小时观察到NE吸收动力学的这些变化.
结论:
- 由于战斗造成的社会压力会改变大脑皮层中北上腺素的再吸收.
- 与压力作斗争导致对诺拉上腺素再吸收的亲和力下降,可用的吸收部位数量增加.
- 压力诱导的变化也导致对d-安非他胺的亲和力降低,抑制了对诺尔上腺素的吸收.
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