12,13-环氧三角 9-trichothecenes作为可能的真菌毒素,负责树脂菌毒素毒性
概括
树虫产生有毒化合物,包括三种12,13-环氧-Delta(9) -trichothecenes,这可能是动物中树虫毒性病的原因. 进一步分析发现了罗丁E和两个相关化合物.
科学领域:
- 菌类学 菌类学是指菌类学.
- 毒理学 毒理学 毒理学
- 自然产品化学 自然产品化学
背景情况:
- Stachybotrys atra是一种已知产生真菌毒素的真菌.
- 树突毒素症是一种与暴露于Stachybotrys atra.产生的毒素相关的疾病.
- 由S. atra产生的特定有毒代谢物需要进一步阐明.
研究的目的:
- 为了识别和描述在麦上培养的Stachybotrys atra产生的有毒化合物.
- 为了研究这些真菌毒素的化学性质.
- 确定这些化合物的潜在作用,在stachybotryotoxicosis.
主要方法:
- 在麦上培养Stachybotrys atra.
- 毒性化合物的提取和分离.
- 谱分析 (例如,NMR,MS) 用于结构性确定.
- 盐水杀伤性测定用于毒性评估.
主要成果:
- 从S. atra培养物中分离出了对盐水有毒的五种化合物.
- 其中三种化合物被确定为12,13-环氧-三角 (9-trichothecenes).
- 一个确定的三甲是罗里丁E,这是Myrothecium verrucaria的一个已知的代谢产物.
- 另外两种化合物被水解成维鲁卡罗尔,这是已知的罗里丁和维鲁卡林的水解产物.
- 光谱数据证实,剩余的两种化合物也是12,13-环氧-三角 (9-trichothecenes).
结论:
- 草本植物 (Stachybotrys atra) 产生一种有毒的12,13-环氧-三角 (9-trichothecenes) 混合物.
- 这些已识别的三合甲基,包括罗里丁E和维鲁卡罗尔衍生物,很可能是致病菌的致病原体.
- 可能需要进一步的研究,以充分了解这些代谢物的毒理学特征.
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