相关实验视频
Updated: Aug 6, 2026

11:46
Single Molecule Analysis of Laser Localized Psoralen Adducts
Published on: April 20, 2017
概括
纯 lysergic acid diethylamide (LSD) 在中等剂量时似乎不会对人类造成染色体损伤或遗传突变. 研究表明,观察到的染色体异常更可能与一般药物滥用有关,而不是与LSD本身有关.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 遗传学和分子生物学
- 生殖健康 生殖健康
背景情况:
- 早期研究表明,lysergic acid diethylamide (LSD) 可能会诱导染色体破裂和遗传损伤.
- 在体外和体内研究的结果相互矛盾,需要对LSD的基因毒性和致病性潜力进行全面的审查.
研究的目的:
- 评估LSD诱导的染色体损伤的证据,以及人类的突变性,致癌性和致癌性.
- 为了区分纯LSD与非法LSD制剂的影响.
主要方法:
- 在体外和体内染色体研究的系统审查和分析.
- 检查暴露于纯粹和非法LSD的人类受试者的数据.
- 对动物模型中多索菲拉的突变性和原性研究的综述.
主要成果:
- 试管体内研究显示出混合的结果,损害往往发生在无法实现的人类暴露水平.
- 在体内研究表明,与纯LSD相比,非法LSD使用者的染色体异常率显著更高.
- 纯LSD仅在极高剂量时表现出微弱的突变效应,与人类使用无关;在人类中没有显著的致病性或致癌性影响.
结论:
- 在使用者身上观察到的染色体损伤可能与一般药物滥用有关,而不是纯LSD.
- 纯LSD,中等剂量,似乎不会在体内引起可检测的染色体或遗传损伤.
- 纯LSD在人类中不被认为是致癌物或致癌物,这表明控制的实验性使用在怀孕之外是可以接受的.
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