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Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
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亚人类灵长类二分化细胞:可能是生产病毒疫苗的基质

J C Petricciani, H E Hopps, D E Lorenz

    Science (New York, N.Y.)
    |December 3, 1971
    PubMed
    概括

    来自 rhesus 和非洲绿的新子细胞系与人类双胞胎细胞系相似. 这些灵长类细胞系对病毒疫苗的开发和生产有前途.

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    Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...