相关实验视频
Updated: Aug 19, 2026

08:09
Isolation, Culture, and Imaging of Human Fetal Pancreatic Cell Clusters
Published on: May 18, 2014
概括
康卡纳瓦林 (Concanavalin) 一种强烈结合的胎儿人类肠道细胞,与成人细胞不同. 这表明康卡纳瓦林A可能针对胎儿肠道细胞膜上存在的常见抗原.
科学领域:
- 细胞生物学 细胞生物学
- 发育生物学 发展生物学
- 免疫学 免疫学 免疫学
背景情况:
- 细胞表面分子在胚胎发育过程中发生变化.
- 像康卡纳瓦林A这样的聚合素可以揭示细胞表面碳水化合物的差异.
研究的目的:
- 通过使用莱克来研究人类胎儿和成人肠上皮细胞的差异性聚合.
- 探索特定细胞表面抗原在胎儿肠道细胞上的潜在存在.
主要方法:
- 从人类胎儿和成人肠道中分离上皮细胞.
- 使用康卡纳瓦林A和小麦胚芽聚合素的聚合试验.
主要成果:
- 康卡纳瓦林A明显结合的胎儿肠道细胞,但不是成人细胞.
- 小麦胚芽聚合素显示成年肠道细胞的中度聚合.
结论:
- 康卡纳瓦林A的结合在胎儿和成年人肠上皮细胞之间有显著差异.
- 这些发现表明,康卡纳瓦林A可能会识别胎儿肠道细胞膜上存在的常见抗原.
相关概念视频
Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

