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血脑屏障:在 carotid 注射后,吗啡,可代因,海洛因和美沙的透
概括
海洛因迅速穿透血脑屏障,在老鼠中吸收率为68%. 大脑对海洛因的这种快速吸收可能解释了它的成性质.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 药物新陈代谢 药物新陈代谢
背景情况:
- 了解阿片类药物的血脑屏障 (BBB) 透是解释其药理作用和成潜力的关键.
- 以前的研究已经确定了不同类阿片类止痛药的不同程度的BBB透性.
研究的目的:
- 在大鼠中量化大脑对吗啡,可代因,海洛因和甲的吸收.
- 为了研究静脉内注射和动脉内注射途径之间对药物大脑吸收的关系.
- 探索快速透海洛因大脑及其成性质之间的潜在联系.
主要方法:
- 被标记的阿片类药物 (吗啡,可代因,海洛因,甲) 通过注射剂注射到老鼠的常见动脉中.
- 在注射后15秒内,老鼠被首,以测量大脑中药物含量.
- 大脑吸收的药物被计算为与同时注射的高度扩散的参考物质相比的百分比.
主要成果:
- 大脑吸收的百分比为:吗啡 (无法检测),编码因 (24%),海洛因 (68%) 和甲 (42%).
- 对于吗啡和可代因的静脉注射研究显示,与 carotid 注射数据有很好的相关性.
- 在静脉注射后的30秒内,可代因的脑吸收几乎完全完成.
结论:
- 某些阿片类药物,特别是海洛因,在脑中被迅速吸收,这表明它们能有效地穿透血脑屏障.
- 海洛因的快速静脉吸收似乎受到区域大脑血流的影响.
- 海洛因在BBB的迅速透可能是导致其高成潜力的关键因素.
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