概括
绵羊疹的特征性细胞损伤涉及神经元真空化和囊泡芽. 与这种疾病相关的35nm粒子在神经元真空内的细胞质过程中积聚.
科学领域:
- 神经科学是一个神经科学.
- 兽医病理学 兽医病理学
- 传染性疾病 传染性疾病
背景情况:
- 天然疹是一种慢性,退行性和传染性中枢神经系统疾病,影响绵羊.
- 在甲状腺癌中观察到的主要细胞病理包括神经元真空化.
研究的目的:
- 为了表征与绵羊的自然疹相关的细胞病变.
- 调查这些病变中的特定颗粒的存在和位置.
主要方法:
- 对受影响的绵羊中枢神经系统组织进行显微镜检查.
- 超结构分析用于识别细胞结构和粒子.
主要成果:
- 神经真空化和囊泡和细胞质过程的静脉芽被确定为特征性病变.
- 在神经元真空中的细胞质过程中发现了35nm粒子的膜结合积累.
- 这些粒子在有限数量的真空化神经元中被观察到.
结论:
- 观察到的细胞变化,包括颗粒积累,是自然草病的特征.
- 这些发现有助于了解这种在绵羊中传播的海绵状脑病变的病原性.
相关概念视频
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Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
03:03Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...