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在选择性结肠手术中的预防性口服抗菌剂. 一个受控试验试验
Lancet (London, England)
|November 22, 1975
概括
预防性抗生素,包括甲尼达和卡纳米,显著减少结肠细菌和术后伤口感染在结肠手术患者. 这种有效的治疗方案没有显示任何不良副作用.
科学领域:
- 手术感染预防 手术感染预防
- 结肠直肠手术 结肠直肠手术
- 微生物学 微生物学
背景情况:
- 结肠外科手术带来了 postoperative 伤口感染的风险,这是由于居住的微生物群.
- 厌氧细菌是结肠微生物群的重要组成部分.
研究的目的:
- 评估预防性口服美特罗尼达和卡纳米在减少结肠微生物群的疗效.
- 评估这种抗微生物治疗方案对术后伤口感染率的影响.
主要方法:
- 一项受控试验涉及50名接受选择性结肠手术的患者.
- 干预组接受了口服的甲尼达和卡纳米辛.
- 对照组仅接受了饮食和机械制剂.
主要成果:
- 在治疗组中,有氧和无氧结肠微生物群的显著减少.
- 在接受抗生素治疗的患者中观察到术后伤口感染的显著减少.
- 一名对照患者因Bacteroides血清病发生了致命的结局.
结论:
- 预防性口服美트로尼达和卡纳米有效降低结肠微生物群.
- 这种疗法显著降低了结肠手术后术后伤口感染的发生率.
- 研究的预防方案耐受性良好,没有观察到有毒副作用.
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