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预防性马环球蛋白在预防非A,非B型输血后肝炎的有效性
Lancet (London, England)
|March 13, 1976
概括
在心脏手术患者中,输血前马环球蛋白显著降低了输血后肝炎的频率和严重程度. 这种干预措施对非A,非B型病毒性肝炎有效,改善了患者的治疗结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 输血医学 输血医学
背景情况:
- 输血后肝炎仍然是心脏手术患者的一个担忧.
- 乙型肝炎和A型肝炎不是目前大多数输血后肝炎的主要原因.
- 确定有效的预防措施对于患者安全至关重要.
研究的目的:
- 评估输血前马环球蛋白在预防输血后肝炎方面的疗效.
- 为了确定高位乙型肝炎表面抗体 (HbsAb) 马环球蛋白是否比正常马环球蛋白提供更好的保护.
- 评估肝炎发病率和严重程度的整体降低.
主要方法:
- 一个随机的,安慰剂对照试验,涉及279名心脏手术患者.
- 患者在手术前接受高位数HbsAb马环球蛋白,正常马环球蛋白或安慰剂.
- 对患者进行了9个月的监测,以检测肝炎的血清学证据和黄等临床症状.
主要成果:
- 47名患者发生肝炎,10名患者出现黄.
- 与安慰剂相比,马环球蛋白接受者经历的黄性肝炎显著减少 (P = 0.003).
- 在马环球蛋白组中,肝炎的总体频率显著降低;两种马环球蛋白制剂之间没有显著差异.
- 乙型肝炎和A型肝炎感染很少见;细胞巨乳病毒在3名患者中被检测到.
结论:
- 输血前的马环球蛋白有效降低了输血后肝炎的发生率和严重程度.
- 保护作用扩展到非由甲型肝炎或乙型肝炎病毒引起的肝炎.
- 马环球蛋白的使用是一种可行的策略,可以减轻输血相关的肝炎风险.
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