在一家普通医院的 Gentamicin 耐药性 Pseudomonas aeruginosa 和 Serratia marcescens 在一家普通医院
Lancet (London, England)
|March 13, 1976
概括
在Pseudomonas aeruginosa和Serratia marcescens中,高水平的 جنت米辛耐药性是医院的一个重大问题. 阿米卡辛对抗耐药菌株显示出有效性,提供了可行的治疗选择.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 在常见的医院获得的病原体中抗 gentamicin 耐药性是一个日益增长的临床挑战.
- Pseudomonas aeruginosa 和 Serratia marcescens 是 nosocomial 感染的重要原因.
研究的目的:
- 评估Pseudomonas aeruginosa和Serratia marcescens分离物中抗 gentamicin 的流行情况.
- 评估耐药菌株对替代抗生素的体外敏感性,包括阿米卡辛,托布拉米辛和西索米辛.
主要方法:
- 标准化磁盘测试和阿加稀释方法被用于确定抗 gentamicin 的耐药性.
- 在临床隔离物中确定了最小抑制度 (MIC).
- 对阿米卡辛,托布拉米辛和西索米辛进行了敏感性测试.
主要成果:
- 19.1%的Pseudomonas aeruginosa和50.0%的Serratia marcescens分离物是抗 gentamicin 的.
- 80%的耐药临床分离物具有甘他米辛MIC≥16μg/ml.
- 阿米卡辛在对抗抗 gentamicin 的 S. marcescens (100%) 和 Ps. marcescens (100%) 方面表现出很高的疗效. 气球菌 (79%). 气球菌 (79%).
- 托布拉米辛和西索米辛对珍塔米辛的优势有限.
- 大多数分离物来源于尿路,其中一些也在血液培养物中发现.
- 耐药菌株表现出与敏感菌株相似的毒性.
- 在17名用阿米卡治疗的患者中,有13名患者观察到临床改善.
结论:
- 在Ps.中存在高频率的 gentamicin 耐药性. aeruginosa和S. marcescens是一个持续的问题.
- 阿米卡辛是一种有效的治疗选择,用于由抗 gentamicin 菌株引起的感染.
- 这些发现强调了需要在医院环境中持续监测和管理抗菌素耐药性的必要性.
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