概括
患有腹腔隔膜缺陷 (VSD) 的儿童的生长通常不正常,受出生后血液动力学之外的因素的影响. 成功的手术修复可以改善体重,但不能提高身高,这表明复杂的生长决定因素.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 遗传性心脏病研究 遗传性心脏病研究
- 增长与发展研究 研究 研究 研究
背景情况:
- 心室隔膜缺陷 (VSD) 是一种常见的先天性心脏病,与生长受损有关.
- 了解VSD中生长障碍的多因素性质对于有效管理至关重要.
研究的目的:
- 为了研究一个大群VSD患者的生长状况.
- 识别干预前后影响生长的因素.
- 阐明VSD中血液动力学和生长之间的关系.
主要方法:
- 从先天性心脏缺陷自然史联合研究中对1210名VSD患者的回顾性分析.
- 医学管理和手术修复组之间的生长参数 (身高,体重) 的比较.
- 多变量分析以确定入院身高和体重的预测因素.
主要成果:
- 患有VSD的患者在入院时表现出不正常的身高和体重,与生理严重程度和年龄相关.
- 成功的手术修复导致了显著的体重增加,但没有改善身高.
- 医疗管理对非正常生长模式的影响最小.
- 入院身高和体重的关键决定因素包括心脏外异常,出生体重低,入院年龄较大,心力衰竭史以及肺/全身压力和流量比率的改变.
结论:
- 在VSD中严重的生长障碍不仅仅是由于产后血液动力学变化.
- 宫内因素,遗传学和低出生体重显著导致生长受损.
- 这些因素有助于解释即使在成功修复VSD后也观察到的有限的生长恢复.
相关概念视频
Factors Affecting Pulmonary Ventilation
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Mitral Valve Prolapse I: Introduction
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Mitral Regurgitation I: Introduction
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Atelectasis II: Pathophysiology
Atelectasis develops when alveoli lose their air and collapse inward. Because lung tissue is naturally elastic, these air sacs shrink rather than remaining open. Collapsed alveoli are no longer ventilated, reducing their role in gas exchange. Blood flow may continue in these regions, creating a ventilation–perfusion mismatch. Clinical findings include decreased breath sounds, dullness to percussion, reduced chest expansion, and decreased tactile fremitus as sound transmission through collapsed...


