概括
结肠直肠癌 (CRC) 的原点正在转移,在30年内,远端病变减少,近端病变增加. 这种CRC分布的趋势需要更新的诊断策略,以便更好地早期检测.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 结肠直肠癌 (CRC) 的发生率和位置已经研究了数十年.
- 以前的诊断方法可能无法完全捕捉CRC起源地点的当前趋势.
研究的目的:
- 在至少30年的时间内分析结直肠癌原点分布的变化.
- 评估这些趋势对诊断工具的重要性的影响.
主要方法:
- 在中西部的一家医院观察到的1,990例结肠直肠癌病例的分析.
- 在同一时期,堪萨斯州11635例结直肠癌的死亡率数据的审查.
主要成果:
- 远端 (直肠) CRC病例的统计学显著下降 (P=.0192).
- 临近 (眼皮) 癌症病例的统计学上显著增加 (P=.0015).
- 堪萨斯州的死亡率数据证实了这一趋势 (P<.0001).
结论:
- 转变的CRC源地分布表明风险因素或检测模式正在发生变化.
- 与30年前相比,数字直肠检查和信号显微镜在诊断CRC方面效率较低.
- 便查隐性血液,透水泡和结肠镜检查是结肠直肠癌的越来越重要的诊断工具.
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