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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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Published on: December 28, 2015

在前B细胞系中优先使用最多的JH-近端VH基因段

G D Yancopoulos, S V Desiderio, M Paskind

    Nature
    |October 25, 1984
    PubMed
    概括

    在pre-B细胞中免疫球蛋白基因重组显示出对JH-近端VH基因段的强烈偏好. 这表明染色体组织影响重组率,并塑造了早期的VH基因谱.

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