概括
患有冠状动脉疾病 (CAD) 的患者即使服用β阻塞剂,也可以获得显著的运动训练益处. 这项研究表明,尽管运动期间心率下降,心脏康复是有效的.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 冠状动脉疾病 (CAD) 患者的β-上腺阻塞可能会通过减弱运动诱导的心率和心率输出来限制运动训练的益处.
- 了解β抑制剂对运动能力和训练适应性的影响,对于优化心脏康复计划至关重要.
研究的目的:
- 评估3个月的运动训练计划在接受不同剂量的β-阻断剂的CAD患者的疗效.
- 为了确定β-阻断剂治疗是否会损害运动训练在这个人群中的好处.
主要方法:
- 在35名CAD患者中实施了为期3个月的步行-慢跑-自行车训练计划,分为三个组:没有β-阻断剂,低剂量普罗兰和高剂量普罗兰.
- 在训练干预之前和之后测量了最大运动心率和氧气消耗 (VO2max).
- 训练强度保持在训练前最大心率的70-85%之间.
主要成果:
- 所有组都在训练后显著增加了VO2最大值 (27%没有β抑制剂,30%低剂量,46%高剂量).
- 与没有β-阻断剂的组相比,在两组propranolol组中,最大运动心率显著降低.
- 尽管贝塔抑制剂组的训练心率降低,但观察到大量的训练效应.
结论:
- 在CAD患者中,即使使用治疗剂量的β-阻塞剂和降低训练心率,也可以获得显著的运动训练效益.
- 在接受心脏康复治疗的CAD患者中,显然没有必要降低β-阻断剂剂量.
- 贝塔抑制剂治疗似乎不会影响冠状动脉疾病患者从运动训练中获得的积极适应.
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