在慢性稳定喘中,睡眠期间呼吸不规律和低氧化
Lancet (London, England)
|February 6, 1982
概括
稳定性喘患者的睡眠质量较差,在睡眠期间出现更多的清醒和频繁的氧气脱 (SaO2),特别是在REM睡眠期间. 这些夜间呼吸和氧气水平的变化与白天的SaO2有关,而不是肺功能下降.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 睡眠科学 睡眠科学
- 肺部生理学 肺部生理学
背景情况:
- 喘管理通常侧重于白天的症状,对夜间的干扰不太注意.
- 在患有慢性呼吸道疾病的个体中,睡眠质量和氧气和度可能会受到显著影响.
研究的目的:
- 为了比较呼吸模式,动脉氧和度 (SaO2) 和睡眠阶段,稳定性喘患者与健康对照者在不受干扰的睡眠期间进行比较.
- 研究成年喘患者的夜间低氧症的发生和特征.
主要方法:
- 在10名稳定的喘患者和10名年龄相匹配的健康受试者中,多睡眠学被用来监测呼吸,SaO2和脑电图 (EEG) 睡眠阶段.
- 持续监测发生在整个一个晚上不受干扰的睡眠.
主要成果:
- 与健康对照人群相比,喘患者的睡眠质量较差,其特点是觉醒,嗜睡和呼吸不规则增加.
- 喘患者的SaO2下降幅度明显更大,更频繁,大多数缺血发作发生在快速眼动 (REM) 睡眠期间.
- 夜间低氧症的严重程度与清醒时的SaO2水平相关,但与睡眠后的强迫呼吸量 (FEV) 减少无关.
结论:
- 稳定的喘患者患有睡眠质量受损和夜间氧气脱,主要是在REM睡眠期间.
- 这些与睡眠相关的呼吸系统障碍与基线氧化有关,但不一定与睡眠后急性肺功能减少有关.
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