相关实验视频
Updated: Aug 10, 2026

11:49
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
概括
接受脏移植的接受者在移植前具有T细胞反应性,但在移植时具有负的交叉匹配,在一年后的移植存活率为60%. 这表明成功的移植是可能的,尽管先前T细胞敏感化.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
背景情况:
- 阳性T细胞交叉匹配表明移植排斥的高风险.
- 移植前的T细胞反应性的临床意义,但在移植时缺席,仍然不清楚.
研究的目的:
- 评估高敏感性患者的移植前T细胞反应性但在移植时负交叉匹配的移植存活率.
主要方法:
- 对15名高度敏感的移植接受者进行了观察性研究.
- 患者接受了阿扎西奥普林,普雷尼松和子抗细胞血清的免疫抑制.
- 移植后至少1年的随访.
主要成果:
- 60% (9/15) 的患者保持了正常运作的移植,平均血清肌氨酸为1.6 mg/dL.
- 在12名患者中发生了早期的移植不功能.
- 由于早期的急性幽默排斥 (1) 和慢性排斥 (2),发生了移植损失.
- 14名患者在移植前显示T细胞对正常淋巴细胞的反应性下降.
- 在移植时具有供体特异性B细胞抗体的4名患者中,有3名患者丢失了移植的移植物.
结论:
- 在高度敏感,T细胞反应性过渡的患者中,脏移植可能会成功.
- 移植时存在供体特异性B细胞抗体与较高的移植损失有关.
相关概念视频
Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

