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Updated: Oct 2, 2026

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在塞浦路斯的贝塔沙拉塞米亚的临床多样性的分子基础

J S Wainscoat, J M Old, D J Weatherall

    Lancet (London, England)
    |June 4, 1983
    PubMed
    概括

    贝塔沙拉血症的临床变异性受阿尔法沙拉血症和特定的β-环球蛋白基因突变的影响. 了解这些因素使得早期产前诊断能够更好地管理.

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    The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...