在性结肠炎中进行癌症监测. 经验超过15年的经验
Lancet (London, England)
|July 16, 1983
概括
定期监测性结肠炎患者的发育不良是至关重要的. 早期检测和干预显著降低了长期结肠炎病例中的结肠直肠癌风险.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 结肠直肠手术 结肠直肠手术
背景情况:
- 广泛的性结肠炎 (UC) 增加了结肠直肠癌的风险.
- 长期存在的UC需要对癌前变化进行警监测.
研究的目的:
- 评估定期临床评估和粘膜活检在检测广泛性结肠炎患者的失塑性变化的有效性.
- 确定患有长期UC的患者患有形和癌症的发病率,并评估监测对患者结局的影响.
主要方法:
- 从1966年到1980年,对303名患有放射性广泛性性结肠炎的患者进行了随访.
- 定期进行临床评估和粘膜活检,以检测失塑性变化.
- 分析了患者数据,包括疾病持续时间,发育不良等级和癌瘤发育.
主要成果:
- 在没有癌症的8名手术治疗的患者中发现了中度或重度的发育不良.
- 186名患者中有13名患有癌瘤,病史为10年或更长时间.
- 在16例确诊的癌症中,有11例是早期癌症 (杜克斯A或B型),有1例患者在15年内死于癌症.
结论:
- 在广泛的性结肠炎中,定期监测缺血症对于早期癌症检测至关重要.
- 患有10年或更长时间广泛的性结肠炎的患者应考虑进行直肠切除术或密集的随访.
- 监测可能预防了8例癌症,并使11例患者的早期诊断成为可能,改善了治愈能力.
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