阿兹特雷诺姆与 gentamicin 相比,用于治疗严重的尿路感染
Lancet (London, England)
|June 16, 1984
概括
阿兹特雷诺姆在治疗严重的尿路感染方面表现出高的疗效和安全性,表现出比珍塔米辛更好的结果,特别是在尿路异常的患者中. 它为阿米诺糖化物提供了一个有前途的替代品.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学 是一个学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 严重的尿路感染 (UTI) 带来了重大治疗挑战.
- 阿米诺糖化物,如 جنت米辛是常用的,但可能有毒作用.
- 需要新的抗生素来有效和安全地管理尿路感染.
研究的目的:
- 为了比较aztreonam与gentamicin在治疗严重尿路感染中的疗效和安全性.
- 评估尿道异常对治疗结果的影响.
- 评估常见的尿路感染病原体对阿兹特雷诺姆和 جنت米辛的体外敏感性.
主要方法:
- 随机对照试验涉及52名严重尿路感染的患者.
- 患者接受了阿兹特里奥纳姆 (35) 或珍塔米辛 (17).
- 评估的结果包括治愈率,复发,再感染,治疗失败和不良事件. 进行了体外敏感性测试.
主要成果:
- 相比于 gentamicin (9 个不合格的治疗, 1 个复发, 4 个再感染),阿兹特雷诺姆的治愈率更高 (23 个不合格的治愈, 6 个复发, 6 个再感染).
- 对于阿兹特雷诺姆,没有出现治疗失败的情况,而对于 gentamicin,失败率为3个. 泌尿器官异常显著影响了结果.
- 阿兹特雷诺姆的毒性作用 (肝功能异常) 比 جنت米辛 (功能恶化) 较少.
- 与阿兹特雷诺南 (14/46) 与珍塔米辛 (1/17) 相比,观察到与D组链球菌的尿道殖民率更高.
- 在体外,有97%的グラム阴性分离物对阿兹特雷诺姆和91%的 gentamicin 敏感.
结论:
- 阿兹特雷诺姆是一种有效和安全的替代品,用于治疗严重的尿路感染,特别是在尿路异常的患者.
- 虽然aztreonam显示D型链球菌殖民的发病率较高,但其整体安全性和有效性概况是有利的.
- 进一步的研究可能会探索策略,以减轻 aztreonam 治疗的二次殖民的风险.
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