概括
在婴儿中,角膜炎/结节炎/咳 (DTP) 疫苗显示出比角膜炎/结节炎 (DT) 疫苗的哭泣和发烧略高一些. 平面DTP疫苗导致更多的接种后症状,而不是吸附的DTP或DT疫苗.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 疫苗学 疫苗学 疫苗学
背景情况:
- 常规的婴儿免疫接种对于公众健康至关重要.
- 对医疗保健提供者和家长来说,了解疫苗安全概况至关重要.
- 通常使用的是白/结节炎/咳 (DTP) 和白/结节炎 (DT) 疫苗.
研究的目的:
- 为了将常规初级免疫接种后的疫苗接种后症状与吸附的DTP和DT疫苗进行比较.
- 评估与DTP和DT疫苗相关的特定不良事件的频率.
- 为了评估疫苗配方 (吸收与普通) 对疫苗接种后症状的影响.
主要方法:
- 一项涉及6004名接受吸附DTP疫苗的婴儿和4024名接受吸附DT疫苗的婴儿的比较研究.
- 在每次接种疫苗后,对接种后症状进行系统监测和记录.
- 包括1000多剂普通DTP疫苗,以评估其安全性.
主要成果:
- 与吸附的DT相比,吸附的DTP与哭泣,尖叫和发烧的轻微增加有关.
- ,白/色与软弱,局部反应发生在两个吸附疫苗的频率相似.
- 在吸附的DTP和DT疫苗的第三剂后,观察到局部反应的显著增加.
- 与吸附制剂相比,普通DTP疫苗导致疫苗接种后症状的发生率更高.
结论:
- 吸附的DTP和DT疫苗在大多数不良事件中具有相似的安全概况,发烧和哭泣反应略有不同.
- 当地反应随着随后的吸附疫苗剂量增加.
- 与吸附配方相比,普通DTP疫苗可能与更高的疫苗接种后症状负担有关,这需要进一步调查.
相关概念视频
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