在西非的输血中心,查乙型肝炎病毒标志物是不合理的
Lancet (London, England)
|August 25, 1984
概括
一些儿童在输血后患有乙型肝炎病毒 (HBV) 感染,但持续携带者很少见. 目前不建议在该地区对输血进行常规HBV查.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 乙型肝炎病毒 (HBV) 在撒哈拉以南非洲造成严重的健康负担,儿童患病率很高.
- 输血是HBV传播的潜在途径,特别是当没有进行查时.
研究的目的:
- 为了调查严重贫血儿童接受未经查的血液输血的乙型肝炎病毒 (HBV) 感染的发生率.
- 评估输血后持续性HBV感染和临床显著性肝炎的发生率.
主要方法:
- 在冈比亚,一组62名严重贫血的儿童接受了全血输血,而没有先前进行乙型肝炎表面抗原 (HBsAg) 查.
- 儿童在六个月内被监测HBV感染标志物和肝酶水平,有些人被跟踪了一年.
主要成果:
- 在输血之前,在捐赠者 (89%) 和接受者 (44%) 中都观察到HBV标志物的高患病率.
- 在12周内,37%的以前未感染的儿童感染了HBV感染,但在一年后,只有一人成为持续的HBsAg携带者.
- 持续性HBV感染或临床重要肝炎的发生率与未输血儿童相比.
结论:
- 未经查的血液输血导致部分儿童感染HBV,但持续的携带不常见.
- 目前该地区输血中心的HBV查计划由于持久感染率低,流行性高,因此无法证明是合理的.
相关概念视频
Blood Transfusion
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Yellow Fever
Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...


