相关实验视频
Updated: Jul 25, 2026

09:43
Measurement of Heme Synthesis Levels in Mammalian Cells
Published on: July 9, 2015
概括
球蛋白进化涉及基因重复,导致不同的鸟类和哺乳动物胚胎基因. 自然选择,而不是中性漂移,推动了这些全球蛋白基因进化中的变化.
科学领域:
- 进化生物学 进化生物学
- 分子进化分子进化
- 基因组学就是基因组学.
背景情况:
- 全球氨基酸和血球蛋白基因序列数据的快速增长.
- 克拉迪斯蒂克分析揭示了对全球进化的新见解.
- 之前的研究表明,肌球蛋白从全球蛋白祖先的独立进化.
研究的目的:
- 研究鸟类和哺乳动物胚胎α和β环球蛋白基因的进化起源.
- 确定基因复制和自然选择在全球蛋白进化中的作用.
- 挑战全球蛋白分子进化的中立主义假设.
主要方法:
- 对全球蛋白的氨基酸序列进行克拉迪斯学分析.
- 对血红蛋白基因和伪基因的核酸序列的分析.
- 遗传学重建以推断基因重复事件.
主要成果:
- 鸟类 (pi) 和哺乳动物 (xi) 胚胎阿尔法基因起源于大约4亿年前的一次单基因事件,在阿尔法-β基因分离之后.
- 独立的β基因重复后来产生了鸟类胚胎rho和哺乳动物胚胎epsilon/胎儿gamma loci.
- 证据支持自然选择对重复的基因起作用,这与中立主义观点相矛盾.
结论:
- 全球蛋白演变的特点是基因重复事件塑造了不同血统中的基因家族.
- 鸟类和哺乳动物胚胎球蛋白位的进化是独立发生的.
- 自然选择在全球蛋白序列的适应性进化中发挥了重要作用,驳斥了纯粹中立的解释.
相关概念视频
The Evidence for Evolution
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.The collection of fossils within sedimentary rocks give a record of common ancestry and often depicts the history of evolution.
Convergent Evolution
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.The structures that arise from convergent evolution are called analogous structures. They are similar in function even if they are dissimilar in structure. Further, structures can be analogous while also...
Gene Families
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Protein Families
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key locations, protein...
Synteny and Evolution
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral chromosome underwent...
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral chromosome underwent...
Gene Duplication and Divergence
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.

