在高血压患者中,急性和慢性蒂莫洛尔治疗引起的血液动力学,反射和代谢变化
Circulation
|January 1, 1978
概括
蒂莫洛尔在患有基本高血压的患者中有效降低血压. 这项研究发现,抗高血压剂蒂莫洛尔降低了动脉压和心脏指数,其效果与普罗普拉诺洛尔相似.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学 是一个学科.
背景情况:
- 基本高血压是一种常见的疾病,需要有效的治疗.
- β抑制剂是一种用于管理高血压的药物.
- 蒂莫洛尔是一种β-上腺素受体抑制剂,具有潜在的抗高血压特性.
研究的目的:
- 评估在患有基本高血压的患者中,急性和长期治疗蒂莫洛尔的血液动力学,心血管和代谢效应.
- 为了比较静脉注射和口服蒂莫洛尔的效果.
- 为了评估蒂莫洛尔作为抗高血压剂的有效性.
主要方法:
- 包括16名患有轻度至中度基本高血压的患者.
- 研究了静脉注射蒂莫洛尔的急性影响.
- 在四周的口服蒂莫洛尔治疗中评估了长时间的效果.
- 测量了血液动力学参数,包括平均动脉压,心脏指数和总周围阻力.
- 此外,还评估了血仁素活性,血体积和心血管反射.
主要成果:
- 口服蒂莫洛尔在15名完成者中显著降低了躺卧时的静脉缩 (7%),静脉缩 (9%) 和平均动脉压.
- 静脉注射和口服蒂莫洛尔都降低了心脏指数 (分别为20%和13%).
- 随着静脉注射蒂莫洛尔,总周边电阻增加,随着口服治疗,恢复到基线.
- 静脉注射蒂莫洛尔降低了左心室喷射率,但在口服治疗中恢复正常.
- 在这两种施用途径下,血仁素活性同样降低.
- 在13名患者中,8名患者的血体积下降.
- 对瓦萨尔瓦机动的反射反应发生了变化,但对直立倾斜或握手的反射反应没有变化.
结论:
- 蒂莫洛尔是一种有效的口服抗高血压药物,用于控制基本高血压.
- 蒂莫洛尔的血液动力学和代谢作用与普罗普拉诺洛尔的效果相似.
- 蒂莫洛尔显著降低了血压和心脏输出,对周围抵抗和心室功能有显著影响.
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