心血管疾病死亡率趋势和年轻女性口服避孕药的使用情况
Lancet (London, England)
|November 13, 1976
概括
口服避孕药的使用与15-44岁女性心血管疾病死亡率的增加有关. 使用者患心脏病,高血压和中风的风险更高,即使使用较低剂量的药丸.
科学领域:
- 心血管流行病学心血管流行病学
- 生殖健康 生殖健康
背景情况:
- 口服避孕药 (OCs) 被生育年龄的女性广泛使用.
- 之前的研究表明,OCs与心血管风险之间存在联系,但范围和特定疾病受到争论.
研究的目的:
- 分析15-44岁女性口服避孕药患病率和心血管疾病死亡率趋势之间的关联.
- 量化OC使用者的特定心血管疾病死亡相对风险与非使用者的相比.
主要方法:
- 分析了来自21个国家的死亡率数据.
- 心血管疾病死亡率趋势 (非风湿性心脏病,高血压,脑血管疾病) 与口服避孕药患病率变化的相关性.
- 估计口服避孕药使用者心血管死亡的相对风险.
主要成果:
- 在15-44岁的女性中,增加口服避孕药的使用和较高的非风湿性心脏病,高血压和脑血管疾病死亡率之间发现了显著的关联.
- 对心脏病/高血压来说,死亡的相对风险估计为5: 1,对脑血管疾病来说是2:1,对于所有心血管疾病来说是3:1.对于OC用户与非用户来说.
- 在不同的雌激素剂量中观察到增加的风险,包括新的低剂量配方.
结论:
- 口服避孕药的使用与生育年龄妇女因一系列血管疾病增加的死亡率密切相关.
- 确定的风险可能比以前认识到的要大,不仅限于高剂量雌激素药片.
- 这些发现强调了考虑口服避孕药使用者的心血管风险的重要性,无论药物的配方如何.
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