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对delta-9-tetrahydrocannabinol对灵长类动物月经周期的破坏性影响产生耐受性

C G Smith, R G Almirez, J Berenberg

    Science (New York, N.Y.)
    |March 25, 1983
    PubMed
    概括

    长期暴露于德尔塔9-四化大麻会扰乱 rhesus 子的月经周期. 然而,耐受性发展,导致正常周期和荷尔蒙水平随着时间的推移而恢复.

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    The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...