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抗维生素D3的纤维细胞具有可免疫检测的1,25-二氧维生素D3受体

J W Pike, S Dokoh, M R Haussler

    Science (New York, N.Y.)
    |May 25, 1984
    PubMed
    概括

    患有维生素D3依赖性II型的患者具有受体缺陷. 虽然激素结合异常,但存在维生素D受体蛋白,表明结构变异,而不是合成问题.

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    Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...