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Updated: May 11, 2026

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
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Published on: February 22, 2019

在转染的L细胞中表达出血溶性活跃的小鼠补充剂的第四成分

D D Chaplin, R Sackstein, D H Perlmutter

    Cell
    |June 1, 1984
    PubMed
    概括

    研究人员在小鼠中确定了功能补充成分4 (C4) 基因. 将C4-Y基因引入L细胞产生了功能性C4,证明L细胞能够正确处理这一关键的免疫蛋白.

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    Complement System01:27

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    The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...