概括
产生青素酶的球菌在1976年出现,使青素治疗无效. 斯펙티노마이신 (spectinomycin) 的成功率很高,而青素酶稳定的头类对于未来的淋病治疗有前途.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 在英国出现产生青素酶的尼塞利亚淋病菌株 (PPNG).
- PPNG菌株获得了TEM类型的青素酶,这种青素酶在格拉姆阴性细菌中很常见.
- PPNG分离物很快成为普遍存在的,到1976年在利物浦达到9%.
研究的目的:
- 评估PNG感染的临床影响.
- 评估不同抗微生物药物对PPNG的疗效.
- 突出诊断测试和替代治疗方法的需要.
主要方法:
- 对45名感染PNG的患者进行临床观察.
- 对青素,分红素和四环素的治疗疗效评估.
- 在实验室中测试青素酶稳定的头类的敏感性.
主要成果:
- 在所有PNG感染病例中,青素治疗都失败了.
- 斯佩克提诺米辛的成功率达到了95% (21/22名患者).
- 环素的成功率为68% (13/19名患者).
- 青素酶稳定的头类体在体外表现出活性.
结论:
- PPNG感染没有显示减少传染性或侵入性.
- 标准的青素治疗对PPNG无效.
- 斯佩克提诺米是一种有效的治疗方法; 青素酶稳定的头类素是潜在的未来选择.
- 实验室检测PPNG是至关重要的,因为在英国传播.
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