概括
在对其他药物无反应的53%的患者中,托卡因治疗有效地控制了心室节律失常. 长期使用显示了轻微的副作用,有效性最好通过持续的门诊心电图监测来评估.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 临床电生理学 临床电生理学
背景情况:
- 心室心律不整是一个重大的临床挑战.
- 传统的抗心律失常药物 (金尼丁,普罗卡因胺,普罗兰) 通常是无效的或耐受性较差的.
- 托卡因胺是利多卡因的口服类型,为治疗耐火性心律失常提供了潜在的替代方案.
研究的目的:
- 评估托卡尼德在耐火性心室失常症患者的长期疗效和安全性.
- 确定评估长期抗心律失常药物疗效的最佳方法.
主要方法:
- 一组17名患有复发性或症状性心室节律失常的患者,对其他治疗不耐药,接受了托卡因德.
- 托卡因胺剂量在每8小时内从300毫克到700毫克不等,并对血度进行监测.
- 通过减少心律失常,症状控制和长期随访来评估有效性.
主要成果:
- 在17名患者中有9名 (53%) 患有托卡尼德控制的心律失常.
- 在8名患者中,治疗没有成功,其中3人在治疗期间死亡.
- 轻微的副作用通常耐受良好,7名患者继续长期治疗.
- 门诊心电图记录对于评估药物疗效至关重要,特别是在无症状心律不整时.
结论:
- 托卡因在耐火性心室节律失常症患者的一个子组中显示出中度的疗效.
- 长期托卡尼德治疗可能是安全有效的,但副作用很小.
- 顺序的门诊心电图监测是评估长期抗不律性药物疗效的首选方法.
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