Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

65.0K
Overview
65.0K
Humoral Immune Responses01:36

Humoral Immune Responses

66.4K
Overview
66.4K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.8K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.8K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

14.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.6K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

2.4K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The genetic control of immune responses.

Immunology today·2014
Same author

Correlation between molecular structure and helicity of induced chiral nematics in terms of short-range and electrostatic-induction interactions. The case of chiral biphenyls.

Journal of the American Chemical Society·2001
Same author

A critical role for lymphotoxin-beta receptor in the development of diabetes in nonobese diabetic mice.

The Journal of experimental medicine·2001
Same author

DR, DQ, and you: MHC alleles and autoimmunity.

The Journal of clinical investigation·2001
Same author

Discovering the role of the major histocompatibility complex in the immune response.

Annual review of immunology·2000
Same author

HLA class II transgenic mice: models of the human CD4+ T-cell immune response.

Immunological reviews·2000
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
查看所有相关文章

相关实验视频

Updated: May 7, 2026

Murine Model of CD40-activation of B cells
12:24

Murine Model of CD40-activation of B cells

Published on: March 6, 2010

12.0K

鼠类Eαα免疫反应基因

D J Mathis, C O Benoist, V E Williams

    Cell
    |March 1, 1983
    PubMed
    概括
    此摘要是机器生成的。

    研究人员特征了小鼠Eα基因,这是主要基因相容性复合体的关键组成部分. 这种免疫反应基因与其人类对应物具有保存的结构和功能,通过转录调节.

    更多相关视频

    Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
    11:40

    Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation

    Published on: October 20, 2014

    8.1K
    Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
    08:47

    Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

    Published on: May 8, 2016

    23.9K

    相关实验视频

    Last Updated: May 7, 2026

    Murine Model of CD40-activation of B cells
    12:24

    Murine Model of CD40-activation of B cells

    Published on: March 6, 2010

    12.0K
    Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
    11:40

    Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation

    Published on: October 20, 2014

    8.1K
    Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
    08:47

    Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

    Published on: May 8, 2016

    23.9K

    科学领域:

    • 免疫遗传学 免疫遗传学
    • 分子生物学分子生物学

    背景情况:

    • 主体组织相容性复合体 (MHC) 在免疫反应中起着至关重要的作用.
    • Eα基因是MHC中的免疫反应基因.

    研究的目的:

    • 隔离和测序cDNA和小鼠Eα基因的基因克隆.
    • 为了比较小鼠Eα基因与人类同类基因DRα.
    • 为了研究Eαα基因表达的转录调节.

    主要方法:

    • 隔离和cDNA和基因组克隆的测序.
    • 鼠类和人类基因之间的比较序列分析.
    • 分析不同类型细胞中的基因表达模式.

    主要成果:

    • 在小鼠Eα基因和人类DRα基因之间观察到相同的内子-外子结构.
    • 蛋白质编码序列,特别是免疫球蛋白类折叠的序列,保存良好.
    • 非编码序列的保护性较低,除了促进区外.
    • 不同基因表达是通过转录来调节的,显然不需要基因组重组.

    结论:

    • 鼠类Eα基因与人类DRα基因具有显著的结构和序列相似性.
    • 转录调节是控制各种细胞类型中Eα基因表达的主要机制.