评估β阻断剂班德罗夫卢胺和普拉佐辛在严重高血压中的作用
Lancet (London, England)
|February 5, 1977
概括
对于严重的高血压,将bendrofluazide或prazosin添加到β-阻断剂治疗中可以显著降低血压. 普拉佐辛显示出略有较大的减少,而bendrofluazide则导致的下降.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 严重的基本高血压往往需要多种药物来有效控制血压.
- 在某些患者中,单独使用β-阻断剂可能不足以达到目标血压.
研究的目的:
- 为了比较bendrofluazide与prazosin在严重基本高血压患者中作为β-阻断剂的附加疗法的疗效.
- 评估三种药物治疗方案的安全性和有效性,当初始的补充疗法不足时.
主要方法:
- 这是一项患者内部随机交叉试验,涉及20名患有严重基本高血压的患者.
- 患者除了现有的β抑制剂疗法外,还接受了bendrofluazide (每天5毫克,然后10毫克) 或prazosin (每天定位至5毫克三次).
- 如果双重治疗不足,那么一小部分患者接受了这三种药物.
主要成果:
- 将bendrofluazide添加到β-封锁剂中,使得站立平均血压平均下降了13%.
- 将普拉佐辛添加到β阻塞剂中,使得站立平均血压平均下降16%.
- 在18名患者完成了试验后,平均站立血压为139/93毫米升;在8名患者中,普拉佐辛与头有关,而bendrofluazide在一半的患者中导致低血压.
结论:
- 班德罗夫胺 (5毫克) 是一种有效的补充药物,用于患有非必要高血压的患者,该高血压无法通过β-阻断剂得到充分控制.
- 普拉佐辛是一种有效且适合的第三线药物,用于治疗严重的基本高血压.
- 组合疗法可以在耐药病例中实现显著的血压降低.
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