概括
在移植患者的乙型肝炎监测中,在8年内发现了6例抗原血症病例. 在3名免疫抑制患者中发生了潜在的乙型肝炎感染的重新激活,这突显了对移植护理的新关注.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 移植医学 移植医学
背景情况:
- 乙型肝炎感染在免疫功能低下的人群中存在风险.
- 长期监测对于了解临床环境中的病毒动态至关重要.
研究的目的:
- 研究移植和透析单位患者和工作人员中乙型肝炎感染的发生率和影响.
- 在移植候选人中确定过去乙型肝炎病毒 (HBV) 感染的患病率.
- 评估免疫抑制移植受体中HBV重新激活的风险.
主要方法:
- 自1968年以来,在工作人员和患者中对乙型肝炎抗原血症进行了监测.
- 查初始患者血清B型肝炎核心抗体 (抗HBc) 以确定之前的感染.
- 移植后监测患者,特别是那些接受免疫抑制治疗的患者,以检测HBV的活性.
主要成果:
- 在8年的时间里,在患者中观察到6例B型肝炎抗原血症.
- 在380名入院患者中,有23人 (6.1%) 检测出抗HBc阳性,这表明他们此前感染了HBV.
- 三名先前感染HBV的患者在移植后免疫抑制时经历了抗原血症,这表明重新激活.
结论:
- 潜在的乙型肝炎感染可以在免疫抑制下在移植患者中重新激活.
- 乙型肝炎的重新激活是管理移植接受者的重要考虑因素.
- 需要加强警和策略,以控制移植中的乙型肝炎.
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