概括
左心室功能障碍和心室节律失常独立预测心肌梗塞后的死亡率. 减少左心室射出分数预测早期死亡,而心室心律失常预测晚期死亡.
科学领域:
- 心脏病学 心脏病学
- 临床医学 临床医学
- 生物统计学 生物统计学
背景情况:
- 心肌梗塞 (MI) 幸存者面临心室失常和左心室功能障碍的风险.
- 预测MI后的死亡率需要了解这些因素的相互作用.
研究的目的:
- 调查心室失常,左心室功能障碍和后心脏病患者死亡率之间的独立和联合关系.
- 为了确定左心室喷射分数 (LVEF) 和心室过早脱极化 (VPDs) 的预测值,以确定死亡时间.
主要方法:
- 对766名心脏病后心脏病患者的分析,评估排放前24小时心电图对于心室过早脱极化 (VPD) 的频率和重复性.
- 放射性核素腹腔镜测定左心室喷射分数 (LVEF),二分体化为30%.
- 统计分析相关联了LVEF,VPD特征和死亡率,调整了混变量.
主要成果:
- 低于30%的LVEF (危险比率3.5),VPD运行 (危险比率1.9) 和高VPD频率 (危险比率2.0) 是显著的死亡预测因素.
- 关于死亡风险的LVEF,VPD频率和重复性之间没有发现显著的相互作用.
- LVEF<30%预测了早期死亡率 (<6个月),而心室心律失常预测了晚期死亡率 (>6个月).
结论:
- 降低的LVEF和心室节律失常都是心肌梗塞后死亡的独立预测因素.
- 死亡的时间不同,LVEF预测早期事件,心律失常预测后期事件.
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