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Updated: Jun 27, 2026

Long-term In Vivo Tracking of Inflammatory Cell Dynamics Within Drosophila Pupae
09:26

Long-term In Vivo Tracking of Inflammatory Cell Dynamics Within Drosophila Pupae

Published on: June 14, 2018

编码Drosophila粘合蛋白的可扩展基因不会在缺乏远程上游序列的变体中表达

M A Muskavitch, D S Hogness

    Cell
    |July 1, 1982
    PubMed
    概括

    在Drosophila melanogaster中的遗传变异

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    In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

    Published on: August 20, 2019

    Multiplex Detection of Gene Expression in the Intact Drosophila Brain Using Expansion-Assisted Iterative Fluorescence In Situ Hybridization09:05

    Multiplex Detection of Gene Expression in the Intact Drosophila Brain Using Expansion-Assisted Iterative Fluorescence In Situ Hybridization

    Published on: May 2, 2025

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    Genome Size and the Evolution of New Genes03:21

    Genome Size and the Evolution of New Genes

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    Position-effect Variegation02:32

    Position-effect Variegation

    In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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    The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
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    Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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