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Updated: Sep 27, 2026

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新皮质早期细胞死亡量的局部差异预测成人局部专业化

B L Finlay, M Slattery

    Science (New York, N.Y.)
    |March 18, 1983
    PubMed
    概括

    新皮质的早期细胞损失反向预测成年神经元数量. 这种细胞死亡特别影响上皮层厚度,塑造局部大脑发育.

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    Determination01:51

    Determination

    During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...