概括
这项研究表明,使用激活凝血时间 (ACT) 监测的肝素协议对于治疗静脉血栓和肺栓塞是安全有效的. 严格遵守协议将风险降至最低,并确保成功的患者结果.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 静脉血栓栓塞 (VTE),包括深静脉血栓塞和肺栓塞,需要有效的抗凝治疗.
- 氨酸是一种广泛使用的抗凝剂,需要仔细监测,以保持治疗疗效,并尽量减少出血风险.
研究的目的:
- 评估VTE患者的活性凝血时间 (ACT) 监测指导的连续肝素协议的安全性和有效性.
- 建立一个标准化协议,用于氨酸的管理和过渡到华法林治疗.
主要方法:
- 一组134名经证实VTE的患者接受了连续抽肝素治疗.
- 该方案涉及初始玻尿酸注射,随后进行持续输注,调整以保持ACT水平在150-190秒之间.
- 在治疗ACT的2-3天后开始服用口服华法林,在达到目标前热血素时间比率后停止服用肝素.
主要成果:
- 该方案取得了很高的成功,在134名患者中,有132名患者在没有肝素失效的情况下作出反应.
- 由于过度服用肝素剂量,两名患者经历了显著的出血.
- 一些患者表现出缓慢的反应或轻微的出血,通常与目标范围之外的ACT水平相关.
结论:
- 连续肝素协议,与ACT监测,是管理静脉血栓和肺栓塞的安全有效的方法.
- 严格遵守既定协议对于优化患者的治疗结果和最大限度地减少不良事件至关重要.
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