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通过口服服用的25-基胆,维生素D和紫外线作为循环25-基维生素D的决定因素的比较
Lancet (London, England)
|June 25, 1977
概括
在提高25-基维生素D (25-OHD) 水平方面,25-基胆化硫醇 (25-OHD3) 比维生素D更有效. 了解这些剂量反应关系有助于诊断维生素D状况,并突出自然保护对缺乏.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 代谢过程中的代谢.
背景情况:
- 维生素D对于平衡和骨健康至关重要.
- 测量循环中的25-氧维生素D (25-OHD) 是评估维生素D状态的标准.
- 口服25-基胆硫醇 (25-OHD3) 和维生素D用于补充,但重要的是要了解它们的相对功效.
研究的目的:
- 为了比较口服25-基胆化硫醇 (25-OHD3) 和维生素D在增加循环中的25-OHD度方面的疗效.
- 为了研究这两种化合物的剂量反应关系.
- 评估25-OHD3相对于维生素D的治疗功效.
主要方法:
- 超过200名受试者接受了25-OHD3或维生素D的短期和长期口服治疗.
- 在5年的时间内测量了循环中的25-OHD水平.
- 用功率函数模型分析了剂量反应曲线.
主要成果:
- 要达到等效的血25-OHD度,需要比25-OHD3更多的维生素D10倍.
- 血25-OHD水平显示了两种化合物的剂量与功率功能关系.
- 这些发现表明,25-OHD3.3的治疗功效优越.
结论:
- 在提高25-OHD水平方面,25-基胆硫醇 (25-OHD3) 比维生素D要强大得多.
- 剂量反应数据对于诊断维生素D状态是有价值的.
- 对维生素D25-基化和紫外线影响的限制可能会防止冬季维生素D缺乏.
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