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Updated: May 10, 2026

Mouse Fetal Liver Culture System to Dissect Target Gene Functions at the Early and Late Stages of Terminal Erythropoiesis
06:40

Mouse Fetal Liver Culture System to Dissect Target Gene Functions at the Early and Late Stages of Terminal Erythropoiesis

Published on: September 9, 2014

全球蛋白mRNA在终端分化小鼠红血球血清癌细胞中的稳定性

V Volloch, D Housman

    Cell
    |February 1, 1981
    PubMed
    概括

    重新评估了在分化MEL细胞中的全球蛋白mRNA稳定性. 新的方法表明,由于细胞培养稳定性的提高,全球蛋白mRNA的半衰期超过60小时,而不是17小时.

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    mRNA Stability and Gene Expression02:51

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    The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
    Cis-acting Elements involved in mRNA stability