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Updated: Jul 15, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

通过组合方法分析和预测蛋白质β片结构

F E Cohen, M J Sternberg, W R Taylor

    Nature
    |June 5, 1980
    PubMed
    概括

    本研究介绍了一种算法,用于从序列和二次结构中预测蛋白质的三级结构. 它成功地模拟了像免疫球蛋白域,β2-微型球蛋白和HLA-B7抗原片段这样的β-表蛋白.

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    Protein Organization01:13

    Protein Organization

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    Protein Organization

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    Protein Folding

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    Protein Organization

    Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
    The primary structure of a protein is its amino acid sequence.
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    Protein Folding

    Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
    Protein Structure Is Critical to Its Biological Function
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