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Updated: Aug 7, 2026

DNA Vector-based RNA Interference to Study Gene Function in Cancer
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Published on: June 4, 2012

脂质体作为基因载体:小鼠L细胞通过提米丁酶基因的高效转化

M Schaefer-Ridder, Y Wang, P H Hofschneider

    Science (New York, N.Y.)
    |January 8, 1982
    PubMed
    概括

    脂质体介导基因转移成功地将丁胺基酶引入小鼠L细胞,创建了一个稳定的转化细胞系. 这种方法为研究应用中的基因改造提供了可行的替代方案.

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    To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.