体重和随后的糖尿病
JAMA
|August 27, 1982
概括
超重预示着糖尿病风险,特别是在高风险女性中. 该组的超重也表明了更严重的糖尿病状况,强调了风险分层对糖尿病预测的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 公共卫生 公共卫生
背景情况:
- 肥胖是一个与代谢障碍相关的全球健康问题.
- 糖尿病的预测标志物对于早期干预至关重要.
- 孕期葡萄糖不耐受是未来糖尿病的已知危险因素.
研究的目的:
- 为了前性地评估体重对糖尿病的10至16年的预测值.
- 评估超重状态是否预测女性糖尿病发病率,并进行正常的葡萄糖耐受性测试.
- 为了确定体重是否预测高风险个体的糖尿病严重程度.
主要方法:
- 一项前性队列研究,涉及女性,最初的葡萄糖耐受性测试正常.
- 分析了两个组:高风险 (先前的过渡性妊娠性葡萄糖不耐受) 和负对照对象.
- 糖尿病发病率和严重程度被追踪了10年至16年,体重被分类为正常或超重.
主要成果:
- 超重的高风险女性患糖尿病的发病率 (46.7%) 与正常体重的高风险女性 (25.6%) 相比明显更高.
- 在对照组中,超重 (4.5%) 和正常体重 (1.9%) 之间的糖尿病发病率差异并不显著.
- 超重状态不是糖尿病的实质性预测因素,除非存在高风险分类;过重预测高风险女性糖尿病严重程度更高.
结论:
- 体重是糖尿病发病率和严重程度的重要预测因素,但只有在存在其他高风险因素的情况下.
- 仅仅超重状态是不足以预测糖尿病的妇女以前正常的葡萄糖耐受性.
- 风险分层,包括体重和妊娠期葡萄糖不耐症史,对于准确预测糖尿病是必不可少的.
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